Brewer was a four-year letterwinner for the Lions where she won 69 games on the mound. During her tenure, the Lions went 150-51 overall. She won seven games as a freshman in 1994, but was 23-3 in 1995, 27-7 in 1996 and 12-7 in 1997.

Brewer ranks second all-time at Southern in appearances (113), complete games (77), innings pitched (619) and strikeouts (438) while being fourth in saves (5) and fifth in ERA (1.20). She was a four-time All-MIAA selection. Brewer was also a third team All-American selection in 1995.

Brewer was an accounting major at Southern, graduating in 1997. She is currently an accountant with GHE Insurance in St. Louis. Holly and her husband, Steve, live in St. Peters, Mo.